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BIOCHEMISTRY 204 · ENERGY METABOLISM
LECTURE 9 · SLIDE 22
The citric acid cycle
Eight steps, one acetyl-CoA in, oxaloacetate regenerated
THE EIGHT STEPS
1Acetyl-CoA + oxaloacetate → citrate
2Citrate → isocitrate (aconitase)
3Isocitrate → α-ketoglutarate + NADH
4α-KG → succinyl-CoA + NADH
5Succinyl-CoA → succinate + GTP
6Succinate → fumarate + FADH₂
7Fumarate → malate (hydration)
8Malate → oxaloacetate + NADH
YIELD PER TURN
NADH3
FADH₂1
GTP1
CO₂2
PER GLUCOSE · 2 TURNS
6 NADH · 2 FADH₂ · 2 GTP · 4 CO₂
SCHOOL OF BIOLOGICAL SCIENCES
22
3 steps, 3 NADH
“Don’t memorise eight steps. Memorise where the NADH comes from.”
“Steps three, four and eight. Those are your three.”
“Everything else in the column follows from those.”
4:38 / 9:20
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Survivorship bias

Why the planes that came back tell you almost nothing, and the ones that did not tell you everything.

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